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. 2014 Jun 1;20(16):2606–2620. doi: 10.1089/ars.2013.5406

FIG. 3.

FIG. 3.

Ubiquinol-10 delayed the progression of AHL in SAMP1 mice. (A–C) ABR hearing thresholds were measured at high (32 kHz) (A), middle (16 kHz) (B), and low (8 kHz) (C) frequencies at 2, 7, 13, and 19 months of age for SAMP1 mice fed control (●) or ubiquinol-10-supplemented diets started from young (⋄), middle age (gray square) and old age (gray triangle) (n=2–5). (D) Real-time PCR analysis of Sirt1, Pgc-1α, and Sirt3 mRNA expression levels in the cochleae from 7-month-old SAMP1 mice fed a control or ubiquinol-10-supplemented diet (n=5). *p<0.05. (E) Western blot analysis of SIRT1, PGC-1α, SIRT3, SOD2, and IDH2 protein levels in cochleae from 10-month-old SAMP1 mice fed a control or ubiquinol-10-supplemented diet (n=5). *p<0.05. ABR, auditory brainstem response; AHL, age-related hearing loss; IDH2, isocitrate dehydrogenase 2.