Table 4. Kinase Selectivity Data for 3a and Related Compounds.
cpd | GSK-3β IC50 (μM) | HipK2 IC50 (μM) | Dyrk1 IC50 (μM) | CDK2 IC50 (μM) |
---|---|---|---|---|
3a | 0.13 | 0.03 | 0.8 | 26 |
3b | 0.7 | 0.05 | 0.02 | >30 |
3c | 1.0 | 0.02 | 1.7 | >30 |
4e | 2.6 | 0.06 | 2.6 | >30 |
4g | 1.4 | <0.003 | 0.4 | >30 |
5b | 0.25 | <0.003 | 0.06 | 14 |
5f | 6 | 0.57 | 5.4 | >30 |