Table 3. SAR of Thiazole Substituted Analogues.

^aCumulative doses (0.1, 0.3, 1, 3, and 10 mg/kg) were administered incrementally as 5 min i.v. infusions at 0, 20, 40, 60, and 80 min. QTc intervals (ΔQTc) were measured and recorded at each time point as a percent change from baseline for each animal. Values are mean ± SEM (n = 3).