Table 1. Inhibition of HCV RNA in the Replicon Systema.
For 5–10, 12–14 WT 1a and 1b replicon data is the average of n = 3; for NS4B binding, data is the average of n = 6. For 11, WT 1a, 1b, and NS4B binding represent n = 506, 523, and 24, respectively. An analysis of variance (ANOVA) model was fit and used to link values to the compounds (see Supporting Information).