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. 2012 May 24;3(7):565–569. doi: 10.1021/ml300090x

Table 5. Rat and Dog DMPK Profile for 21.

  rat (21)a dog (21)a
clearance 20 1.1
Vdss 4.1 0.9
PO T1/2 3 10
AUC0–24 3800 52000
%F 98% 65%
a

Dosed as a solution in DMSO/Solutol/20% HPβCD (10:10:80); IV dosed 1 mg/kg; PO dosed 5 mg/kg; clearance (mL/min/kg); Vdss (L/kg); T1/2 (h), AUC (ng·h/mL).