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. 2012 Sep 20;3(10):793–798. doi: 10.1021/ml300144n

Table 4. In Vitro Potency of Compounds 17a–c.

graphic file with name ml-2012-00144n_0012.jpg

compd R1 h-11β-HSD-1 IC50a (nM) m-11β-HSD-1 inh. at 100 nMb (%)
17a OH 6.0 26
17b CN 43 9.5
17c COOMe 124 14
a

Average of at least two replicates.

b

The mean of at least two experiments.