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. 2012 Feb 6;3(4):273–277. doi: 10.1021/ml200256d

Table 2. Physicochemical Properties of BAs.

BA Wsa (μM) CMCb (mM) STCMCc (dyn/cm) Log PAd albumin binding (%)
CA (1)6 273 9.2 48 1.1 50
CDCA (2) 32 3.0 46 2.2 93
INT-777 (3) 99 2.0 50 1.4 62
4 188 10 50 1.1 58
7 120 5.9 53 1.6 83
a

Ws: water solubility as protonated species in 0.1 M HCl water solution.

b

CMC: critical micellar concentration determined in 0.15 M NaCl water solution.

c

STCMC: surface tension at CMC in 0.15 M NaCl water solution.

d

Log PA (octanol/water partition coefficient of the ionized species): lipophilicity.