Table 2. Physicochemical Properties of BAs.
BA | Wsa (μM) | CMCb (mM) | STCMCc (dyn/cm) | Log PAd | albumin binding (%) |
---|---|---|---|---|---|
CA (1)6 | 273 | 9.2 | 48 | 1.1 | 50 |
CDCA (2) | 32 | 3.0 | 46 | 2.2 | 93 |
INT-777 (3) | 99 | 2.0 | 50 | 1.4 | 62 |
4 | 188 | 10 | 50 | 1.1 | 58 |
7 | 120 | 5.9 | 53 | 1.6 | 83 |
Ws: water solubility as protonated species in 0.1 M HCl water solution.
CMC: critical micellar concentration determined in 0.15 M NaCl water solution.
STCMC: surface tension at CMC in 0.15 M NaCl water solution.
Log PA (octanol/water partition coefficient of the ionized species): lipophilicity.