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| cmpd | Clp ((mL/min)/kg) | T1/2 (h) | PO AUCN (μM·h·kg/mg) | Foral (%) | FAST (deg·h) |
|---|---|---|---|---|---|
| 9f | 22 | 1.7 | 0.39 | 29 | 2.6 |
| 9g | 86 | 2.1 | 0.34 | 14 | 3.7 |
| 9h | 33 | 1.8 | 0.90 | 11 | 0.4 |
| 9i | 44 | 1.9 | 0.65 | 14 | 2.6 |
Sprague–Dawley (SD) rat was used.
Plasma clearance (Clp) and half-life (T1/2) calculated following 0.5 mg/kg IV dose. Normalized oral exposure (PO AUCN) and oral bioavailability (Foral) calculated following 1.0 mg/kg PO dose.
