Skip to main content
. 2012 Jan 21;3(3):252–256. doi: 10.1021/ml200304j

Table 4. Pharmacokinetic Dataa of Compounds 13 and 14.

species Clp ((mL/min)/kg) T1/2 (h) PO AUCN (μM·h·kg/mg) Foral (%)
rat-(13) 33 2.5 1.05 100
rat-(14) 16 11 1.60 93
dog-(14) 2.9 18 10.0 100
rhesus-(14) 1.3 33 12.0 58
a

Plasma clearance (Clp) and half-life (T1/2) calculated following 0.5 mg/kg IV dose. Normalized oral exposure (PO AUCN) and oral bioavailability (Foral) calculated following 1.0 mg/kg PO dose.