Table 4. Pharmacokinetic Parameters of 8.

	mg/kg
species	iv dose	oral dose	oral AUC(0–t) (μM h)	iv t1/2	iv CL (mL/min kg)	Vdss (L/kg)	F (%)
mousea	4	10	19.3	1.52	10.1	1.66	58
ratb	1	2	0.81	1.73	34.0	5.10	42
dogc	1	2	15.6	7.00	2.34	1.52	53
rhesusc	1	2	14.4	7.21	3.09	1.74	65

^aThe compound was dosed as 1.0 mg/mL solution in EtOH:PEG400:water (2:23:75).

^bThe compound was dosed as 1.0 mg/mL solution in EtOH:PEG400:water (20:30:50).

^cThe compound was dosed as 4.0 mg/mL solution in EtOH:PEG400:water (10:40:50).