. 2012 Jan 23;3(3):248–251. doi: 10.1021/ml200293c

Table 1. Inhibition of the NorA-Mediated Efflux of EtBr in SA-1199B Cells and of the Pgp-Mediated Cell Efflux of R123 in Mouse T Lymphoma L5178 MDR1 Cells.

Cpd ID^a	common name	% inhibition of EtBr efflux	% inhibition of R123 efflux
1^b	reserpine	84.8^c	N.A.
2	amlodipine	60.6	52.8^d
3	astemizole	80.6	12.8^d
4	dipyridamole	42.3	4.7^e
5	loperamide	77.7	4.5^d
6	quinidine	31.5	21.1^e
7	aripiprazole	92.3	99^e,^f
8	ebastine	88.3	99^e,^f
9	sertindole	81.8	74^e,^f
10	ziprasidone	86.6	19^e,^f
11	aprindine	51.6	16^e,^f
12	repaglinide	14.0	35^e,^f
13^g	cyclosporine A	N.A.	92^e,^f
14^h	alprenolol	N.A.	5.0^e,^f
15		22.8ⁱ	44.1^e
16		23.6ⁱ	64.7^e
17		33.9^j	1.9^e
18		1.7^j	2.6^d
19		4.4^j	3.2^e
20		91.2^k	40.6^e
21		19.7^f	16.8^e
22		88.2^c	4.3^e
23		88.4^c	1.6^e
24		0^c	2.3^e
25		30.6^c	21.7^e
26		86.6^c	7.8^d
27		0^c	2.2^e
28		2.8^c	2.1^e
29		71.7^c	0.6^d
30		41.8^c	2.6^e
31		41.3^c	20.4^e
32		81.0^c	0.7^d
33		15.5^c	2.6^e
34		74.7^c	1.7^d
35		0^c	11.3^e

Structures for compounds 1–35, IUPAC names for compounds 15–35, and SMILES are given as Supporting Information.

Reserpine was used as a positive control for EtBr efflux inhibition.

From ref (16).

Tested at 10^–5 M concentration.

Tested at 10^–4 M concentration.

From ref (18).

Cyclosporine A was used as a positive control for R123 efflux inhibition.

Alprenolol was used as a negative control for R123 efflux inhibition.

ⁱ

From ref (21).

From ref (22).

From ref (17).