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. 2012 May 29;3(7):524–529. doi: 10.1021/ml300045b

Table 3. Cellular Activitya.

graphic file with name ml-2012-00045b_0005.jpg

      PI3Kβ IC50 (μM) MDA-MB-468 (μM)
no. R1 R2   pAKT EC50 proliferation gIC50
18 2-Me,3-CF3 Me 0.0006 0.024 0.103
19 2-Me,3-Cl Me 0.0005 0.019 0.032
20 2-Me,3-CF3 Et 0.0005 0.016 0.023
21 2-Me,3-CF3 c-Pr 0.0005 0.009 0.043
26 2-Me,3-Cl CH2OH 0.0001 0.006 0.008
28 2-Me,3-Cl OMe 0.0003 0.006 0.021
32 2-Me,3-Cl NH2 0.0002 0.003 0.026
a

IC50 values given are means of at least two experiments