Table 4. In Vitro 11β-HSD1 Inhibitory Activity, Liver Microsomal Stability, and 11β-HSD 1 Inhibition of Cyclic Sulfonamide Derivatives.
(E)-Adamantylcarboxamide isomer.
IC50 values were determined by GraphPad Prism software.
The chirality of methyl is racemic. Results of in vivo 11β-HSD1inhibition are expressed as means ± SEMs for n = 4 mice per group. **P < 0.01, ***P < 0.001 vs vehicle group.