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. 2012 Jan 17;3(2):88–93. doi: 10.1021/ml200226x

Table 4. In Vitro 11β-HSD1 Inhibitory Activity, Liver Microsomal Stability, and 11β-HSD 1 Inhibition of Cyclic Sulfonamide Derivatives.

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a

(E)-Adamantylcarboxamide isomer.

b

IC50 values were determined by GraphPad Prism software.

c

The chirality of methyl is racemic. Results of in vivo 11β-HSD1inhibition are expressed as means ± SEMs for n = 4 mice per group. **P < 0.01, ***P < 0.001 vs vehicle group.