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| entry | hHSD2 inhibition | plasma stability | CYP inhibition | hERG | aqueous solubility | acute toxicity |
|---|---|---|---|---|---|---|
| 18e | 20% at 10 μM | 100% after 30 min incubation | 1A2 > 100 μM | 36.9 μM | 361 μM | LD50 > 1000 mpk |
| 2C9 > 100 μM | ||||||
| 2C19 > 100 μM | ||||||
| 2D6 > 100 μM | ||||||
| 3A4 > 100 μM |
