Table 2. Predicted Binding Free Energies/Standard Deviations Relative to Chaetochromin A^a.

compound	ΔΔG	SD
chaetochromin A (1)	0.0	1.5
talaroderxine A (2)	–4.7	2.1
cephalochromin (5)	1.4	1.5
skyrin (6)	0.2	1.1
7H	–2.6	1.3
8H	0.7	1.6
9H	–0.3	2.8

^aRelative free energies were computed using the Thermodynamic Integration method and are reported in kcal/mol.^19,20