Table 2. Decay-Corrected Biodistribution of [64Cu]1 in U87MG Tumor-Bearing Mice Quantified by micoPET Imaging (n = 5)a.
tissueb | 2 h | 2 h (blockade) | 4 h | 20 h |
---|---|---|---|---|
Percent Injected Dose/gram (% ID/g) | ||||
T | 4.96 ± 0.73 | 0.71 ± 0.30 | 4.11 ± 0.54 | 2.41 ± 0.31 |
M | 0.42 ± 0.05 | 0.27 ± 0.04 | 0.36 ± 0.07 | 0.35 ± 0.05 |
L | 1.76 ± 0.35 | 1.16 ± 0.15 | 1.64 ± 0.23 | 1.25 ± 0.23 |
K | 2.23 ± 0.21 | 2.09 ± 0.28 | 1.79 ± 0.20 | 0.69 ± 0.26 |
Tumor-to-Normal Tissue Uptake Ratio | ||||
T/M | 11.88 ± 1.31 | 2.52 ± 0.81 | 11.65 ± 1.83 | 7.03 ± 1.22 |
T/L | 2.85 ± 0.28 | 0.60 ± 0.22 | 2.51 ± 0.16 | 1.96 ± 0.26 |
T/K | 2.22 ± 0.26 | 0.33 ± 0.11 | 2.32 ± 0.35 | 3.87 ± 1.26 |
The results are presented as mean ± SD (n = 5).
T, tumor; M, muscle; L, liver; K, kidneys.