Table 3. M₁ FLIPR, Protein Binding, P-gp, and hERG Data for Select Compounds.

^aValues represent the numerical average of at least two experiments. The interassay variability was ±30% (IP, nM), unless otherwise noted.

^bPassive permeability (10^–6 cm/s) in Madin Darby canine kidney (MDCK) cells.

^cMDR1 directional transport ratio (B to A)/(A to B). Values represent the average of three experiments, and the interassay variability was ±20%.

^dValues represent the numerical average of at least two experiments. The interassay variability was ±20% (IC₅₀, μM).