Figure 2.

X-ray binding mode of inhibitor 9 (in magenta) in the active site of E. coli MurD ligase (PDB code: 2Y1O). Hydrogen bonds between 9 and the E. coli MurD active site residues (in yellow) and crystal water molecules (in red) are presented as dashed green lines. Comparison of the binding modes of inhibitors I and 9 in the E. coli MurD active site is shown in Figure S4 in the Supporting Information.