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. 2012 Jun 27;3(8):626–630. doi: 10.1021/ml300047h

Table 1. Inhibitory Activity of Compounds 9 and 10 against MurD and MurE Ligases and Their Antibacterial Activity.

  IC50 (μM)
   MIC (μg/mL)
enzyme I 9 10 bacterial strain 9 10
E. coli MurD ligase 35 8.2 ± 0.6 36 ± 5 S. aureus ATCC 29213 8 >128
S. aureus MurD ligase ND 6.4 ± 1.0 100 ± 5 MRSA ATCC 43300 8 >128
E. coli MurE ligase 64%a 180 ± 60 ∼200b E. faecalis ATCC 29212 64 >128
S. aureus MurE ligase ND 17 ± 1.5 >200c E. coli ATCC 25922 >128 >128
        P. aeruginosa ATCC 27853 >128 >128
a

Residual activity (RA) at 500 μM compound.

b

Residual activity at 200 μM compound: 51 ± 2%.

c

No inhibitory activity at 200 μM compound; ND, not determined.