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. 2012 Aug 10;3(9):749–753. doi: 10.1021/ml300162r

Table 1. IC50 Values (nM) for Selected Compounds against Recombinant Human HDACs 1–3 and 6a.

  class I
 class IIb
compd HDAC1 HDAC2 HDAC3b HDAC8 HDAC6
apicidin 11 ± 3 34 ± 2 13 ± 5 750 >10000
2 30 ± 5 70 ± 24 30 ± 7 2200 >10000
5 540 ± 60 2000 ± 500 650 ± 140 N.D. >10000
9 180 ± 16 300 ± 16 100 ± 14 750 >10000
10 200 ± 72 370 ± 48 320 ± 21 N.D. >10000
11 700 ± 160 1200 ± 140 270 ± 4 N.D. >10000
a

IC50 values are means of at least two assays performed in duplicate.

b

In complex with nuclear receptor corepressor 2 (NCoR-2). N.D. = not determined.