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. 2012 Feb 13;3(4):303–307. doi: 10.1021/ml2002955

Table 1. Structure and Anti-HRV Activity of Compounds 6−12.

graphic file with name ml-2011-002955_0003.jpg

          EC50a
compd R n X Y HRV2 HRV14
6 Me 2 O OEt 0.001 0.005
7 Me 2 O Et 0.024 0.088
8 Cl 2 O OEt 0.003 0.019
9 Me 2 O O-nPr 0.003 0.029
10 Me 2 O nPr 0.084 0.013
11 Me 2 S OEt 0.003 0.029
12 Cl 3 O OEt 0.003 0.009
2 Me 2     0.003 0.004
a

Activity in μg mL−1.