Table 3. Pharmacokinetic Parameters of BTA798 Following Oral Administrationa in Rat and Dog.
| rat |
dog |
|||
|---|---|---|---|---|
| parameter | male (n = 28) | female (n = 27) | male (n = 3) | female (n = 3) |
| Cmax (ng mL−1) | 22500 | 17700 | 11000 | 6100 |
| tmax (h) | 16.0 | 11.2 | 14.7 | 7.7 |
| AUC (ng h mL−1) | 483000 | 489000 | 202000 | 121000 |
| t1/2 (h) | 51.6 | 46.4 | 18.3 | 15.9 |
| bioavailability (%) | 94 | 95 | b | b |
a
Single oral dose of 50 mg kg−1 of BTA798 in 1% carboxymethylcellulose. See the Supporting Information for details.
b
Calculated bioavailability was in excess of 100% indicative of enterohepatic recirculation.