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. 2012 Jul 11;3(8):678–682. doi: 10.1021/ml300146q

Table 2. Cell-Based Antiviral Activity of PAP Derivatives 22–27 with RHS Modifications.

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a

EC50 is the concentration of compound that inhibits HIV-1 replication by 50%. For compounds 22–27, the values are the geometric mean of two determinations; all individual values are within 25% of the mean.

b

CC50 is the cytotoxic concentration of compound that reduces viability of uninfected cells by 50%.

c

Nevirapine (NVP) was used as a positive control.

d

Solubility of HCl salt in distilled water.