Table 1. In Vitro Activity.

	Ki (nM)a
compd	1b	3a	1b replicon IC50 50% NHS (nM)b	rat [liver] at 4 h (μM)c
3	0.02	200	10	21
4	0.05	45	19	7.8
5	0.05	12	19	96
6	0.06	130	21	25
7	1.1	1200	ND	ND
8	1.9	520	ND	ND
9	0.08	26	44	0.6

^aNS3/4a protease time-resolved fluorescence assay, mean of n ≥ 3 measurements.

^bCell-based replicon assay, mean of n ≥ 3.

^cLiver levels from PK experiments described in the Supporting Information.