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. 2012 Mar 2;3(4):332–336. doi: 10.1021/ml300017p

Table 3. Pharmacokinetic Parameters for the Potassium Salt of 15a.

        po
species Clb Vd (L/kg) T1/2 (h) AUC (μM h) [liver] 4 h (μM) [liver] 24 h (μM)
rat 28 3.1 1.4 0.7 23 0.2
dog 5 0.7 3.0 0.4 ND 1.4
a

Rat iv (2 mg/kg, n = 3, DMSO), dog iv (0.5 mg/kg, n = 3, DMSO), rat po (5 mg/kg, n = 3, PEG400), and dog po (1 mg/kg, n = 3, PEG400).

b

mL/min/kg.