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. 2012 Jul 12;3(8):663–667. doi: 10.1021/ml300169x

Figure 1.

Figure 1

Correlation between biochemical and antimicrobial potency of (left) 109 adenine-based inhibitors of H. influenzae LigA against H. influenzae HIN101, a strain lacking the AcrB efflux pump subunit, and (right) 169 adenine-based inhibitors of S. pneumoniae LigA against S. pneumoniae SPN100, which mediate their antibacterial MOA via this target. The triangular pattern is characterized by its hypotenuse, shown as a line displaying a linear relationship between the two parameters when compound permeation is thought not to limit antimicrobial potency. Parallel lines indicate a 95% confidence interval.