Table 2. IC50 Values and Inhibition Rates of the Compoundsa.
| growth inhibition rates toward ES-2 cells |
|||||
|---|---|---|---|---|---|
| compd | IC50 (μM) toward APN on the surface of ES-2 cells | 5 μg/mL | 50 μg/mL | IC50 (μM) toward MMP-2 | IC50 (MMP-2)/IC50 (APN from procine kidney) |
| 4m | 0.48 ± 0.05 | <1.0% | 3.63% | >1000 | >106 |
| 4o | 6.4 ± 0.6 | <1.0% | 6.85% | >1000 | >106 |
| 4q | 0.94 ± 0.08 | <1.0% | 1.78% | 573 ± 35 | 1740 |
| 4s | 1.1 ± 0.1 | <1.0% | 3.29% | >1000 | >106 |
| 4t | 0.79 ± 0.07 | <1.0% | <1.0% | >1000 | >106 |
| 4u | 3.0 ± 0.3 | <1.0% | 2.81% | >1000 | >106 |
| 4v | 6.9 ± 0.6 | <1.0% | <1.0% | >1000 | >106 |
| 4w | 1.5 ± 0.1 | <1.0% | 1.83% | >1000 | >106 |
| 4x | 0.91 ± 0.09 | <1.0% | 11.9% | >1000 | >106 |
| 4cc | 0.42 ± 0.03 | <1.0% | 6.67% | 545 ± 30 | 10900 |
| bestatin | 16.0 ± 1.6 | <1.0% | 2.89% | 276 ± 19 | 30.2 |
a
The compounds were assayed three times, and the results are expressed with standard deviations.