Table 1.

Clinical trials of Rho kinase inhibitors in glaucoma

Compound	Organization	Highest development phase
AMA0076	Amakem, Diepenbeek, Belgium	Phase II
AR-12286*	Aerie Pharmaceuticals Inc., Research Triangle Park, NC, USA	Phase II
AR-13324	Aerie Pharmaceuticals Inc.	Phase III
ATS907*	Altheos Inc., South San Francisco, CA, USA	Phase II
DE-104*	Santen-Ube, Osaka City and Ube City, Japan	Phase II
INS-115644*	Merck, Whitehouse Station, NJ, USA	Phase I
INS-117548*	Merck	Phase I
K-115	Kowa, Aichi, Japan	Phase III
PG324	Aerie Pharmaceuticals Inc.	Phase II
Y-39983; RKI-983; SNJ-1656*	Senju, Tokyo, Japan; and Novartis Pharmaceuticals, Basel, Switzerland	Phase II

Note:

^*Compound development discontinued.