Table 3.

Chaperones of H2A and H3 histone variants and their proposed mechanisms in human cancer

Chaperone	Cancer type	Dysfunction	Proposed mechanism in promoting cancer	References	Variant
SRCAP	Ovarian cancer	Overexpression	N.D.	[89]	H2A.Z
	Metastatic breast carcinoma	Overexpression	N.D.	[84]
	Thyroid carcinoma	Overexpression	N.D.	[85]
	Prostate cancer	Overexpression	N.D.	[86]
	Prostate cancer	N.D.	Deregulation of cell proliferation	[20]
Tip60	Colon carcinomas	Downregulation	N.D.	[88]
	Lung carcinomas	Downregulation	N.D.	[88]
	Breast carcinoma	Downregulation	N.D.	[87]
p400	Breast cancer	Overexpression	Activation of ERα target genes	[17]
HJURP	Lung cancer	Overexpression	Aneuploidy	[227]	CENP-A
	Breast cancer	Overexpression	Aneuploidy	[228]
HIRA	Endothelial cells	Upregulation	Promotion of tumor neovascularization	[264]	H3.3
Daxx	GBM	Mutation	N.D.	[15]
	PanNET	Mutation	Loss of function	[18, 19]
ATRX	ATMDS	Mutation	Deregulation of α-globin expression	[266]	H3.3 (mH2A?)
	GBM	Mutation	Loss of nuclear localization	[15]
	Pediatric DIPG	Mutation	Loss of function	[16]
	Other cancers of the CNS	Mutation	Loss of nuclear localization	[279]
	Neuroblastoma	Mutation/deletion	Loss of function	[274]
	PanNET	Mutation/deletion	Loss of function	[18, 19]