Hypothetical network of proteins found in proteome analysis. Note that (?) suggests a putative compensatory mechanism, which might be operative in the BK−/− urinary bladder (for further information see also Results and Discussion). AC, adenylate cyclase; CAM, calmodulin; CNN, calponin h1; DAG, diacylglycerol; Eno, enolase 3; ER, endoplasmic reticulum; GPCR, G-protein-coupled receptor; GST, glutathione S-transferase; IP3, inositol 1,4,5-trisphosphate; IP3-R, IP3 receptor; MLCK, myosin light chain kinase; MLCP, myosin light chain phosphatase; PKC, protein kinase C; PIP2, phosphatidylinositol 4,5-bisphosphate; PLB, phospholamban; PLC, phospholipase C.