Table 3.
Odds ratios (OR) and 95% confidence intervals (CI) of the risk for gestational diabetes mellitus (GDM) according to maternal early pregnancy elevated urine 8-OHdG concentrations and pre-pregnancy overweight status, Seattle and Tacoma, Washington, USA
| Elevated 8-OHdG & Pre-pregnancy Overweight | GDM Cases (N=55) | Control Subjects (N=43) | Unadjusted OR (95% CI) | *Adjusted OR (95% CI) |
|---|---|---|---|---|
| No & No | 16 (29.1) | 25 (58.1) | 1.00 (referent) | 1.00 (referent) |
| Yes & No | 12 (21.8) | 7 (16.3) | 2.68 (0.87-8.24) | 3.63 (1.09-12.14) |
| No & Yes | 15 (27.3) | 7 (16.3) | 3.35 (1.12-10.01) | 3.06 (0.93-10.01) |
| Yes & Yes | 12 (21.8) | 4 (9.3) | 4.67 (1.29-17.10) | 5.36 (1.33-21.55) |
| P for interaction | 0.49 | 0.46 |
Elevated urine 8-OHdG is defined as maternal urine 8-OHdG ≥ 8.01 ng/mg creatinine (highest quartile in the controls). Pre-pregnancy overweight status is defined as maternal pre-pregnancy BMI≥ 25 kg/m2.
*
Adjusted for maternal age and race/ethnicity