. Author manuscript; available in PMC: 2014 May 19.

Published in final edited form as: Int J Clin Med. 2014 Jan 1;5(3):93–101. doi: 10.4236/ijcm.2014.53017

Table 1.

Efficacy of diclazuril on infected dams in fetomaternal toxoplasmosis model.

Tissues	Control	Infected	Infected + treated
Excess body weight (%)	0	62 ± 1^a	41 ± 2.5^a
Hematocrit (%)	44.5 ± 1.2	37 ± 1.4^a	41.1 ± 2.4
Hepatic weight (g)	1.78 ± 0.25^b	3.4 ± 0.14^b,a	3.18 ± 0.99^a
Colonic length (mm)	125 ± 2.5	87 ± 2.2^a	99 ± 4^a
Heart weight (mg)	202 ± 10	315 ± 30^a	247 ± 18^a
Uterus weight (g)	11.60 ± 0.5^a	13.9 ± 0.7^a	11.9 ± 1.9
Hypersensitivity (%)	20 ± 0.5^b	43 ± 2.5	40 ± 0.4

Tissues from normal control dams (Control), those infected with 600 tachyzoites from PTG strain, treated with sham (infected), and those Diclazuril treated dams (Infected + treated). Animals were monitored daily X3/until Day 16 of pregnancy before termination. Abdominal hypersensitivity to von Fray stimuli increased significantly in infected animals. p value ^b < 0.01; ^a < 0.05.