Skip to main content
. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Trends Genet. 2014 Mar 22;30(4):140–149. doi: 10.1016/j.tig.2014.02.006

Figure 1. Genetic risk-variants mapping to coding regions.

Figure 1

A. Non-synonymous genetic risk-variants alter structure and activity of encoded proteins. A1 and A2 are the two alleles of a genetic risk variant. In all figures, A1 is the normal allele (or risk allele), and A2 is the risk allele (or normal allele).

B. Synonymous genetic risk-variants alter translational rate, further influencing protein folding. R: Ribosome.

C. Genetic risk-variants disrupt exonic splicing enhancers (ESE), further leading to exon skipping. SC: splicing complex.