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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Trends Genet. 2014 Mar 22;30(4):140–149. doi: 10.1016/j.tig.2014.02.006

Figure 2. Noncoding genetic risk variants.

Figure 2

A. Genetic risk variants influence DNA methylation level at promoter regions.

B. Genetic risk variants modulate transcription factor binding to chromatin. TF: transcription factor; PF: pioneer factor; LF: chromatin looping factor.

C. Genetic risk variants alter chromatin loop formation bridging enhancers and promoters.

D. Genetic risk variants influence the repression effect of miRNAs. RISC: RNA-induced silencing complex.

E. Genetic risk variants influence the interaction of lncRNAs with target proteins. NP: nuclear proteins.