A. Genetic risk variants influence DNA methylation level at promoter regions.
B. Genetic risk variants modulate transcription factor binding to chromatin. TF: transcription factor; PF: pioneer factor; LF: chromatin looping factor.
C. Genetic risk variants alter chromatin loop formation bridging enhancers and promoters.
D. Genetic risk variants influence the repression effect of miRNAs. RISC: RNA-induced silencing complex.
E. Genetic risk variants influence the interaction of lncRNAs with target proteins. NP: nuclear proteins.