Trial name or title	Active management of the third stage of labour without controlled cord traction: a randomised non-inferiority controlled trial
Methods	Multi-centre RCT.
Participants	Women giving birth vaginally.
Interventions	Intervention: active management of third stage of labour without CCT: 1)10 units oxytocin IM immediately after birth of baby; 2) delayed cord clamping and 3) placenta delivered by gravity or maternal effort. Comparison: active management of third stage of labour: 1) 10 units oxytocin IM immediately after birth of baby; 2) delayed cord clamping and 3) placenta delivered by controlled cord traction
Outcomes	Primary: blood loss > 1000 mL. Secondary: blood transfusions, additional uterotonic; blood loss > 500 mL; postpartum maternal Hb; maternal death; manual removal of placenta; additional surgical procedures (hysterectomy, ligation of vessels); composite outcome of maternal death and serious morbidity; initiation of breastfeeding; side effects of nausea and abdominal pain
Starting date	November-December 2008.
Contact information	A Metin Gulmezoglu. Email: gulmezoglum@who.int
Notes	Eight centres located in Argentina, Egypt, India, Kenya, Philippines, South Africa, Thailand and Uganda

CCT: controlled cord traction

Hb; haemoglobin

IM: intramuscular

IV: intravenous

RCT: randomised controlled trial