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. Author manuscript; available in PMC: 2014 May 19.
Published in final edited form as: Clin Chem. 2013 Nov 19;60(1):186–196. doi: 10.1373/clinchem.2013.215251

Fig. 1. Circulating 25(OH)D interacts with IRS1 variant on HOMA-IR in women in 4 populations of different ancestries. Predicted values for HOMA-IR (both natural log-transformed) were calculated with regression models, adjusting for potential confounders in the female participants of the BPRHS and MESA Hispanic, African-American, and non-Hispanic white populations.

Fig. 1

With higher circulating 25(OH)D, predicted HOMA-IR decreased more evidently in the IRS1 variant minor allele homozygotes than the major allele carriers in each population. The P values of the interaction for each population were calculated in a general linear model including an interaction term [genotype by 25(OH)D] in the model, and the P values are shown in the respective panel. Number of participants in each population: BPRHS, n = 79 for rs2943641 TT carriers and n = 729 for C allele carriers; MESA Hispanic, n = 62 for rs2673142 CC carriers and n = 573 for G allele carriers; MESA African-American, n = 44 for rs2972144 TT carriers and n = 557 for C allele carriers; and MESA non-Hispanic white, n = 118 for rs1515104 AA carriers and n = 903 for T allele carriers.