Table 3. Results from SelectScreenTM (Invitrogen) kinase profiling of CGS 15943 − other kinases.
| [ATP] tested μM | Kinase tested | % of inhibition (point 1) | % of inhibition (point 2) | % of inhibition (mean) | Difference between data points (point 1 − point 2) | Z’ |
|---|---|---|---|---|---|---|
| Km app | SPHK1 | −6 | −1 | −4 | 5 | 0.65 |
| Km app | EGFR (ErbB1) | −3 | 4 | 1 | 7 | 0.87 |
| Km app | FGFR1 | 0 | 0 | 0 | 1 | 0.82 |
| Km app | FRAP1 (mTOR) | −4 | 14 | 5 | 17 | 0.92 |
| Km app | IGF1R | −6 | −4 | −5 | 2 | 0.77 |
| Km app | INSR | −2 | −4 | −3 | 2 | 0.81 |
| Km app | KIT | −13 | −25 | −19 | 12 | 0.62 |
| Km app | MET (cMet) | −9 | −20 | −15 | 10 | 0.79 |
| Km app | PDGFRA (PDGFR α) | 19 | 13 | 16 | 7 | 0.78 |
| Km app | PTK2 (FAK) | 4 | 5 | 5 | 0 | 0.89 |
| 100 | RAF1 (cRAF) Y340D Y341D | 14 | 11 | 12 | 3 | 0.57 |
| Km app | RET | 4 | 3 | 4 | 1 | 0.91 |
| Km app | SRC | −1 | −6 | −3 | 4 | 0.90 |