Figure 1. Pazopanib and sodium valproate interact to kill multiple sarcoma cell lines. (A) Sarcoma cells were treated with vehicle (VEH, DMSO), pazopanib (PAZ, 5.0 μM) and/or sodium valproate (VAL, 500 μM) as indicated. Cells were isolated 24 h and 48 h after exposure and viability at each time point determined by trypan blue exclusion (n = 3, ± SEM) *P < greater than vehicle control. (B) HT1080 cells were treated with vehicle (VEH, DMSO), pazopanib (PAZ, 2.0 μM, 4.0 μM, 6 μM) and/or sodium valproate (VAL, 250 μM, 500 μM, 750 μM) as indicated. Cells were isolated 24 h after exposure and viability at each time point determined by trypan blue exclusion (n = 3, ± SEM) *P < greater than vehicle control.