Figure 9. Pazopanib and valproate interact to suppress the growth of established HT1080 tumors. Mice were injected in the rear flank with 1.0 × 10⁷ HT1080 cells in 100 μl of growth medium. Fourteen days after tumor cell implantation when tumors had grown to ~50 mm³ (defined as 1.00 in the graph) mice were mice were PO administered vehicle diluent; pazopanib (25 mg/kg, QD); valproate (50 mg/kg BID), or the drugs in combination for 4 d. Animals were monitored daily, tumor volumes taken every 7 d. (Values plotted are the fold change in mean tumor volume at each time point; ± SEM, 8 mice per treatment condition).