Table 3. Effects of rapamycin on tumor development.

Parameters	Control-2	Rap-2	Control-4	Rap-4	Control-5	Rap-5
No. of mice	12	11	32	32	19	18
1st tumor detection	128	160	150	170	180	188
No. effective mice	12	9	32	32	19	18
No. of tumors	12 (100%)	8 (88.9%)	32 (100%)	32 (100%)	19 (100%)	18 (100%)
Mean latency of the 1st tumor, d	176 ± 7.7	197 ± 8.1 +11.9%	191 ± 4.5	194 ± 3.1	192 ± 3.1	209 ± 4.7a +8.9%
Total number of tumors	76	59	212	216	144	123
No. of tumors per mouse	6.3	7.4	6.6	6.8	7.6	6.8
No. of mice with metastases into lung	8 (66.7%)	7 (63.7%)	16 (50.0%)	24 (75.0%)	13 (68.4%)	12 (66.7%)

^a The difference with relevant controls is significant, P < 0.05.