Table 4. Effects of rapamycin on life span and spontaneous carcinogenesis in mice.
| Strain | Sex | No. of mice, C/Ta | Age at start of treatment, mo | Drug, dose and route of treatmentb | Effect on mean life span, % | Effect on carcinogenesisc | References |
|---|---|---|---|---|---|---|---|
| mTOR (Δ/Δ) | M | 10/17 | 0 | No drugs, mTOR hypomorphic model | +22% | ↓ | Wu et al., 201352 |
| F | 24/26 | +10% | ↓ | ||||
| UM-HET3 | M | 357/134 | 20 | In foodd | +9% | No data | Harrison et al., 20093 |
| UM-HET3 | F | 289/144 | 20 | +14% | No data | ||
| UM-HET3 | M | 50/50 | 9 | +10% | No data | Miller et al., 20115 | |
| UM-HET3 | F | 50/50 | 9 | +18% | No data | ||
| HER-2/neu | F | 28/30 | 2 | 1.5 mg/kg, s.c. 6 times per 4 wk | +4% | ↓ | Anisimov et al., 20104 |
| HER-2/neu | F | 12/11 | 2 | 0.45 mg/kg, s.c. 6 times per 4 wk | 0 | ↓ | Present paper |
| 32/32 | 4 | +5% | ↓ | ||||
| 19/18 | 5 | +7% | ↓ | ||||
| 129/Sv | F | 31/35 | 2 | 1.5 mg/kg, s.c. | +4% | ↓ | Anisimov et al., 20116 |
| С57BL/6 | M | 10/10 | 22–24 | 4 mg/kg b.w., i.p. bidaily for 6 wk | Increase | No data | Chen et al., 20092 |
| С57BL/6J | M | 20/20 | 4 | In food | Increase | ↓ | Neff et al., 201313 |
| M | 21/21 | 13 | |||||
| M | 27/27 | 20–22 | |||||
| C57BL/6Nia | M | 44/45 | 19 | In food | No effect | ↓ | Zhang et al., 201312 |
| F | 43/45 | Increase | ↓ | ||||
| Ndufs4−/− | M | No data | 20 d | 8 mg/kg i.p. e.o.d. | +25% | No data | Johnson et al., 201314 |
| F | +38% | ||||||
| M+F | 8 mg/kg i.p. daily | +100% | No data | ||||
| С57BL/6J p53+/− | M | 38/37 | <5 | 1.5 mg/kg, d.w. | +28% | ↓ | Komarova et al., 201210 |
| C57BL/6J p53+/− | M | 38/37 | >5 | 1.5 mg/kg, d.w. | +10% | ↓ | Komarova et al., 201210 and Comas et al., 20129 |
| C57BL/6J p53−/− | M | 17/21 | 2 | 0.5 mg/kg, p.o. × 5 d; break 9 d | +30% | ↓ | |
| Rb1+/− | M | 97/98 | 2–3 | 14 mg/kg, p.o. or or in food | +14% | ↓ | Livi et al., 201311 |
| F | 2–3 | +9% | ↓ | ||||
| С57BL/6J Bmal1−/− | M+F | 73/31 | 3.3 | 0.5 mg/kg d.w. | +50% | No data | Khapre et al., 201453 |
| 129Sv-C57BL/6J Lmna−/− | M+F | 23/23 | 1 | In food | +23% | No data | Ramos et al.8 |
| 11/11 | 1 | 8 mg/kg i.p. e.o.d. | +57% | ||||
| 9/11 | 1 | 8 mg/kg i.p. weekly | +53% | ||||
| C57BL/6J Lmna−/− | M/F | 11/11 | 1 | 8 mg/kg i.p. e.o.d. | +56% |
a C/T, Control/Treatment; bd.w., with drinking water; s.c., subcutaneously; i.p., intraperitoneally; p.o. (per os), gavage; e.o.d., every other day; c↑, increases; ↓, decreases; dIn food, around 14 mg/kg encapsulated rapamycin with food.