Table 2.
Selected significantly changed metabolites in Rag2−/− mice infected with H. hepaticus at 20 week post-infection.
| HMDB | Metabolites | Pathway | Fold | p-value | m/z | RT(min) | KEGG |
|---|---|---|---|---|---|---|---|
| 00671 | Indolelactic acid | Tryptophan metabolism | −7.06 | 0.00135 | 206.0796 | 21.8 | C02043 |
| 00763 | 5-Hydroxyindoleacetic acid | Tryptophan metabolism | −6.51 | 0.00029 | 192.0645 | 17.4 | C05635 |
| 02096 | 3-Indolebutyric acid | Tryptophan metabolism | −3.30 | 0.02198 | 204.1039 | 19.2 | C11284 |
| 00734 | Indoleacrylic acid | Tryptophan metabolism | −1.86 | 0.00246 | 188.0697 | 25.7 | C00331 |
| 02302 | 3-Indolepropionic acid | Tryptophan metabolism | −1.93 | 0.038 | 188.0720 | 13.3 | |
| 00898 | 1-Methylhistamine | Histidine metabolism | +3.03 | 0.00358 | 126.1020 | 1.7 | C05127 |
| 03045 | Ergothioneine | Histidine metabolism | −4.43 | 0.00106 | 230.0948 | 2.3 | C05570 |
| 00714 | Hippuric acid | Phenylalanine metabolism | −3.45 | 4.88E-07 | 180.0645 | 15.1 | C01586 |
| 00821 | Phenylacetylglycine | Phenylalanine metabolism | +1.79 | 0.00912 | 194.0801 | 16.9 | C05598 |
| 00939 | S-Adenosylhomocysteine | Cysteine and methionine | −1.90 | 0.01773 | 385.1272 | 5.9 | C00021 |
| 10381 | LysoPC(15:0) | Glycerophospholipid | −1.68 | 7.31E-05 | 482.3223 | 42.0 | C04230 |
| 10383 | LysoPC(16:1) | Glycerophospholipid | −1.86 | 6.10E-07 | 494.3225 | 41.0 | C04230 |
| 10389 | LysoPC(18:4) | Glycerophospholipid | −3.62 | 2.62E-05 | 516.3112 | 38.3 | C04230 |
| 10395 | LysoPC(20:4) | Glycerophospholipid | −1.80 | 0.0017 | 544.3388 | 42.4 | C04230 |
| 11475 | LysoPE(18:1) | Glycerophospholipid | −1.76 | 0.00798 | 478.2897 | 30.4 | |
| 11482 | LysoPE(20:1) | Glycerophospholipid | −1.63 | 0.00074 | 506.3284 | 34.4 | |
| 11494 | LysoPE(22:5) | Glycerophospholipid | −1.66 | 0.0205 | 526.2897 | 30.0 | |
| 00094 | Citric acid | Citrate cycle (TCA cycle) | −3.69 | 0.00747 | 191.0201 | 1.7 | C00158 |
| 01248 | FAD | Riboflavin/TCA cycle | +1.73 | 0.00052 | 784.1487 | 9.9 | C00016 |
| 00673 | Linoleic acid | Fatty acids | −2.25 | 0.02427 | 281.2456 | 60.6 | C01595 |
| 01388 | Alpha-Linolenic acid | Fatty acids | −1.67 | 0.01169 | 279.2299 | 57.1 | C06427 |
| 02183 | Docosahexaenoic acid | Fatty acids | −1.82 | 0.00907 | 329.2453 | 59.1 | |
| 01999 | Eicosapentaenoic acid | Fatty acids | −2.45 | 0.03266 | 303.2295 | 56.7 | C06428 |
| 01043 | Arachidonic acid | Fatty acids | −3.87 | 0.04086 | 305.2453 | 60.0 | C00219 |
| 00034 | Adenine | Purine metabolism | −1.74 | 0.04098 | 136.0609 | 8.9 | C00147 |
| 00071 | Deoxyinosine | Purine metabolism | −1.66 | 0.04146 | 253.0920 | 9.7 | C05512 |
| 03312 | Daidzein | Isoflavonoid biosynthesis | +2.08 | 0.00589 | 253.0522 | 19.8 | C10208 |
Fold change: + represents up-regulated metabolites in infected animals, while – denotes down-regulated metabolites in infected animals.