Table 1.

Study Selection Criteria

Inclusion criteria	Exclusion criteria
1. 18–65 years of age 2. BMI ≥25 kg/m2 3. Stable body weight (≤±3 kg) in the preceding 3 months 4. Sedentary individuals 5. Otherwise healthy nonsmokers 6. Subjects signed informed consent forms	1. Subjects with significant history or currently suffering from cardiovascular disease, hepatic or renal dysfunctions, cancer • ALT, AST >2.5 times normal range  • Creatinine >2.0 mg/dL  • Clinically significant abnormal ECG 2. Patient taking drugs that could interfere with the study 3. Known to have allergic responses or sensitivity to any of the medication 4. Pregnancy