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. Author manuscript; available in PMC: 2014 May 19.
Published in final edited form as: Nat Cell Biol. 2013 May 5;15(6):614–624. doi: 10.1038/ncb2735

Figure 1.

Figure 1

SIRT1 is expressed in adult NSCs and neural progenitors. (a) SIRT1 is expressed in the nuclei of NESTIN-positive cells in adult NSC and neural progenitor cultures. Immunocytochemistry on adherent monolayer cultures of adult NSCs and neural progenitors using antibodies against SIRT1 (green) and against the NSC/progenitor marker NESTIN (red). DAPI (blue) is a nuclear marker. (b) SIRT1 is expressed in NSCs and neural progenitors in the SVZ of the adult brain. Immunohistochemistry on brain sections of 8-week-old mice using antibodies against SIRT1 (green) and SOX2 (red, upper panel) or Ki67 (red, lower panel). White arrowheads show examples of double-stained cells. Insets show magnification of a cell positive for SIRT1 and SOX2 or Ki67. Merged images include DAPI to illustrate nuclei. Scale bars, 50 μm.

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