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. Author manuscript; available in PMC: 2015 Mar 25.
Published in final edited form as: Circulation. 2014 Jan 7;129(12):1276–1285. doi: 10.1161/CIRCULATIONAHA.113.006611

Figure 4.

Figure 4

Genetic inhibition of S2814-phosphorylation on RyR2 normalizes RyR2 activity in CREM-mice. (A) Line-scan confocal images of atrial myocytes revealed more spontaneous Ca2+-sparks in CREM-mice. (B) Ca2+-spark frequency (CaSF). (C) RyR2 single channels recordings revealed more openings (o) as shown upward deflections from the closed (c) level in CREM-mice. (D) Open probability (Po) of RyR2-channels. Number in the bars indicated the number of cells/channels studied from 3-4 mice. *P<0.05.