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Genetic inhibition of S2814-phosphorylation on RyR2 suppresses the maintenance of AF in CREM-mice. (A) Electrograms of pacing-induced AF in CREM-mice at 5 months of age. (B) Increased incidence of pacing-induced AF in CREM-mice (n=12) at 5 months of age, compared with WT (n=10) and CREM:S2814A mice (n=12). (C) The average duration of the longest AF-episode in each animal induced by pacing. *P<0.05.
