. Author manuscript; available in PMC: 2014 Oct 1.

Published in final edited form as: Br J Haematol. 2013 Aug 16;163(2):268–276. doi: 10.1111/bjh.12507

Table III.

Rate of hospitalization for Acute Chest syndrome (ACS) in β-globin haplotype groups in SIT Trial participants.

Haplotype	N	ACS rate	IRR^* (95% CI) unadjusted	p-value	IRR (95% CI) adjusted^**	p-value
H1,H2 / H2,H2	224	0.16	1.13 (0.84–1.52)	0.42	1.04 (0.76–1.43)	0.79
H1,H1	410	0.15	REF		REF
H1,H3 / H3,H3	99	0.09	0.66 (0.41–1.06)	0.09	0.51 (0.29–0.89)	0.02

Incidence rate ratio (95% confidence interval).

^**

Adjusted for asthma, gender, HBA1/2 deletion status, and HMOX1 promoter repeat class.