Table 5.

Edivoxetine Dose and Plasma Concentration: Time Summary Statistics in Pediatric Patients

	Adolescents			Children
Targeted dose group (mg/kg)	0.1	0.2	0.3	0.1	0.2	0.3
Actual dose range (mg/kg)	0.080–0.105	0.0849–0.217	0.162–0.309	0.080–0.107	0.161–0.212	0.162–0.319
Actual dose range (mg)	3–6	5–12	6–18	2–6	4–12	4–18
N	30	37	30	35	31	34
Plasma Concentration (ng/mL)
n	119	146	124	133	125	143
Mean	6.90	19.3	25.8	7.07	15.3	22.3
SD	4.96	14.2	20.5	5.04	12.3	14.4
Minimum	0.24	0.46	0.41	0.23	0.37	0.46
Median	6.01	16.61	21.00	6.03	12.69	18.80
Maximum	23.56	97.97	113.18	21.15	63.48	67.86
Blood sampling time (h)a
Minimum	1.42	0.67	0.80	0.17	1.25	0.15
Median	9.25	7.72	8.48	7.75	9.42	8.00
Maximum	35.00	32.78	36.00	35.12	33.83	32.67

^aBlood sample collection time relative to edivoxetine dose administration.

0.1=0.1 mg/kg/day; 0.2=0.2 mg/kg/day; 0.3=0.3 mg/kg/day.

N, number of patients; n, number of plasma concentrations; SD, standard deviation.