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. 2014 May 19;9(5):e97559. doi: 10.1371/journal.pone.0097559

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© 2014 Ogier et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Light micrographs of whole mount ossicles. A) Chd7^+/+ malleus. B) Chd7^+/ ^Looper malleus with slight thickening of the neck (red arrowhead) and a manubrium (white arrowhead) protruding at an acute angle. C) Chd7^+/+ incus. D) Chd7^+/ ^Looper incus with deformed glenoid cavity (red arrowhead) and malformation of long process (white arrowhead). E) Chd7^+/+ stapes. F) Chd7^+/ ^Looper stapes, which was small and round with a bone bridge (arrowhead) extending from the tubercle to the otic capsule. Images are representative of 8 Chd7^+/+ and 10 Chd7^+/ ^Looper ears.