Skip to main content
. 2014 Jun 1;24(3):199–209. doi: 10.1089/nat.2013.0476

FIG. 3.

FIG. 3.

Effect of lipid modification on inhibition of HTT expression by ss-siRNAs. (A) List of ss-siRNAs. Subscript “s” indicates PS linkage; 2′-O-Me modified base is shown in uppercase; 2′-F in underlined uppercase; 2′-MOE in enclosed box. Mismatched base is shown in bold and italic. The terminal T has a 5′-(E)vinyl phosphonate. All other linkages are phosphate. (B-D) Effect of increasing concentrations of ISIS 573309, ISIS 573312, and ISIS 573310 respectively. CM: non complementary duplex RNA. C16: location of lipid modification.